Mouse Gut Microbiome and Motor Function (Hindlimb Clasping Scores)
Hindlimb clasping scores across 5 gut microbiome treatments in alpha-synuclein mice, showing microbiome depletion reduces motor deficits.
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| # | Motor function data for beam traversal, pole descent, adhesive removal, and hindlimb scores | |||||
|---|---|---|---|---|---|---|
| 1 | Treatments: SPF = specific pathogen free / colonized; GF = germ-free; Abx= antibiotic treated; ExGF= recolonized GF animals; SCFA= short-chain fatty acid treated | |||||
| 2 | Genotype: WT= wild-type; ASO= Thy1-alpha synuclein, 12-13 weeks of age | |||||
| 3 | Treatment | Hindlimb score | Hindlimb score | Hindlimb score | Hindlimb score | Hindlimb score |
| 4 | SPF | 0 | 0 | 0 | 0 | 0 |
| 5 | SPF | 0 | 0 | 0 | 0 | 0 |
| 6 | SPF | 0 | 0 | 0 | 0 | 0 |
| 7 | SPF | 0 | 0 | 0 | 0 | 0 |
| 8 | SPF | 1 | 1 | 1 | 1 | 1 |
| 9 | SPF | 0 | 0 | 0 | 0 | 0 |
| 10 | SPF | nd | nd | nd | nd | nd |
| 11 | SPF | nd | nd | nd | nd | nd |
| 12 | SPF | nd | nd | nd | nd | nd |
| 13 | SPF | nd | nd | nd | nd | nd |
| 14 | SPF | 2 | 2 | 2 | 2 | 2 |
| 15 | SPF | 1 | 1 | 1 | 1 | 1 |
| 16 | SPF | 1 | 1 | 1 | 1 | 1 |
| 17 | SPF | 1 | 1 | 1 | 1 | 1 |
| 18 | SPF | 2 | 2 | 2 | 2 | 2 |
| 19 | SPF | nd | nd | nd | nd | nd |
| 20 | SPF | nd | nd | nd | nd | nd |
| 21 | SPF | nd | nd | nd | nd | nd |
| 22 | SPF | nd | nd | nd | nd | nd |
| 23 | SPF | nd | nd | nd | nd | nd |
| 24 | GF | 0 | 0 | 0 | 0 | 0 |
| 25 | GF | 0 | 0 | 0 | 0 | 0 |
| 26 | GF | 0 | 0 | 0 | 0 | 0 |
| 27 | GF | 0 | 0 | 0 | 0 | 0 |
| 28 | GF | 0 | 0 | 0 | 0 | 0 |
| 29 | GF | 1 | 1 | 1 | 1 | 1 |
| 30 | GF | nd | nd | nd | nd | nd |
| 31 | GF | nd | nd | nd | nd | nd |
| 32 | GF | nd | nd | nd | nd | nd |
| 33 | GF | nd | nd | nd | nd | nd |
| 34 | GF | nd | nd | nd | nd | nd |
| 35 | GF | 0 | 0 | 0 | 0 | 0 |
| 36 | GF | 1 | 1 | 1 | 1 | 1 |
| 37 | GF | 0 | 0 | 0 | 0 | 0 |
| 38 | GF | 0 | 0 | 0 | 0 | 0 |
| 39 | GF | 1 | 1 | 1 | 1 | 1 |
| 40 | GF | 1 | 1 | 1 | 1 | 1 |
| 41 | GF | nd | nd | nd | nd | nd |
| 42 | GF | nd | nd | nd | nd | nd |
| 43 | GF | nd | nd | nd | nd | nd |
| 44 | GF | nd | nd | nd | nd | nd |
| 45 | GF | nd | nd | nd | nd | nd |
| 46 | Abx | 1 | 1 | 1 | 1 | 1 |
| 47 | Abx | 0 | 0 | 0 | 0 | 0 |
| 48 | Abx | 0 | 0 | 0 | 0 | 0 |
| 49 | Abx | 0 | 0 | 0 | 0 | 0 |
| 50 | Abx | 0 | 0 | 0 | 0 | 0 |
| 51 | Abx | 0 | 0 | 0 | 0 | 0 |
| 52 | Abx | 0 | 0 | 0 | 0 | 0 |
| 53 | Abx | nd | nd | nd | nd | nd |
| 54 | Abx | nd | nd | nd | nd | nd |
| 55 | Abx | nd | nd | nd | nd | nd |
| 56 | Abx | nd | nd | nd | nd | nd |
| 57 | Abx | nd | nd | nd | nd | nd |
| 58 | Abx | nd | nd | nd | nd | nd |
| 59 | Abx | nd | nd | nd | nd | nd |
| 60 | Abx | nd | nd | nd | nd | nd |
| 61 | Abx | 1 | 1 | 1 | 1 | 1 |
| 62 | Abx | 1 | 1 | 1 | 1 | 1 |
| 63 | Abx | 1 | 1 | 1 | 1 | 1 |
| 64 | Abx | 0 | 0 | 0 | 0 | 0 |
| 65 | Abx | nd | nd | nd | nd | nd |
| 66 | Abx | nd | nd | nd | nd | nd |
| 67 | Abx | nd | nd | nd | nd | nd |
| 68 | Abx | nd | nd | nd | nd | nd |
| 69 | Abx | nd | nd | nd | nd | nd |
| 70 | Abx | nd | nd | nd | nd | nd |
| 71 | Abx | nd | nd | nd | nd | nd |
| 72 | ExGF | 0 | 0 | 0 | 0 | 0 |
| 73 | ExGF | 0 | 0 | 0 | 0 | 0 |
| 74 | ExGF | 0 | 0 | 0 | 0 | 0 |
| 75 | ExGF | 0 | 0 | 0 | 0 | 0 |
| 76 | ExGF | nd | nd | nd | nd | nd |
| 77 | ExGF | nd | nd | nd | nd | nd |
| 78 | ExGF | nd | nd | nd | nd | nd |
| 79 | ExGF | nd | nd | nd | nd | nd |
| 80 | ExGF | nd | nd | nd | nd | nd |
| 81 | ExGF | nd | nd | nd | nd | nd |
| 82 | ExGF | 1 | 1 | 1 | 1 | 1 |
| 83 | ExGF | 1 | 1 | 1 | 1 | 1 |
| 84 | ExGF | 1 | 1 | 1 | 1 | 1 |
| 85 | ExGF | 1 | 1 | 1 | 1 | 1 |
| 86 | ExGF | 2 | 2 | 2 | 2 | 2 |
| 87 | ExGF | nd | nd | nd | nd | nd |
| 88 | ExGF | nd | nd | nd | nd | nd |
| 89 | ExGF | nd | nd | nd | nd | nd |
| 90 | ExGF | nd | nd | nd | nd | nd |
| 91 | ExGF | nd | nd | nd | nd | nd |
| 92 | ExGF | nd | nd | nd | nd | nd |
| 93 | ExGF | nd | nd | nd | nd | nd |
| 94 | ExGF | nd | nd | nd | nd | nd |
| 95 | ExGF | nd | nd | nd | nd | nd |
| 96 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 97 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 98 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 99 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 100 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 101 | SCFA | 1 | 1 | 1 | 1 | 1 |
| 102 | SCFA | 1 | 1 | 1 | 1 | 1 |
| 103 | SCFA | 1 | 1 | 1 | 1 | 1 |
| 104 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 105 | SCFA | 0 | 0 | 0 | 0 | 0 |
| 106 | SCFA | 1 | 1 | 1 | 1 | 1 |
| 107 | SCFA | 1 | 1 | 1 | 1 | 1 |
| 108 | SCFA | 2 | 2 | 2 | 2 | 2 |
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