Mouse Gut Microbiome and Motor Function (Hindlimb Clasping Scores)

Hindlimb clasping scores across 5 gut microbiome treatments in alpha-synuclein mice, showing microbiome depletion reduces motor deficits.
# Motor function data for beam traversal, pole descent, adhesive removal, and hindlimb scores
+
1 Treatments: SPF = specific pathogen free / colonized; GF = germ-free; Abx= antibiotic treated; ExGF= recolonized GF animals; SCFA= short-chain fatty acid treated
2 Genotype: WT= wild-type; ASO= Thy1-alpha synuclein, 12-13 weeks of age
3 Treatment Hindlimb score Hindlimb score Hindlimb score Hindlimb score Hindlimb score
4 SPF 0 0 0 0 0
5 SPF 0 0 0 0 0
6 SPF 0 0 0 0 0
7 SPF 0 0 0 0 0
8 SPF 1 1 1 1 1
9 SPF 0 0 0 0 0
10 SPF nd nd nd nd nd
11 SPF nd nd nd nd nd
12 SPF nd nd nd nd nd
13 SPF nd nd nd nd nd
14 SPF 2 2 2 2 2
15 SPF 1 1 1 1 1
16 SPF 1 1 1 1 1
17 SPF 1 1 1 1 1
18 SPF 2 2 2 2 2
19 SPF nd nd nd nd nd
20 SPF nd nd nd nd nd
21 SPF nd nd nd nd nd
22 SPF nd nd nd nd nd
23 SPF nd nd nd nd nd
24 GF 0 0 0 0 0
25 GF 0 0 0 0 0
26 GF 0 0 0 0 0
27 GF 0 0 0 0 0
28 GF 0 0 0 0 0
29 GF 1 1 1 1 1
30 GF nd nd nd nd nd
31 GF nd nd nd nd nd
32 GF nd nd nd nd nd
33 GF nd nd nd nd nd
34 GF nd nd nd nd nd
35 GF 0 0 0 0 0
36 GF 1 1 1 1 1
37 GF 0 0 0 0 0
38 GF 0 0 0 0 0
39 GF 1 1 1 1 1
40 GF 1 1 1 1 1
41 GF nd nd nd nd nd
42 GF nd nd nd nd nd
43 GF nd nd nd nd nd
44 GF nd nd nd nd nd
45 GF nd nd nd nd nd
46 Abx 1 1 1 1 1
47 Abx 0 0 0 0 0
48 Abx 0 0 0 0 0
49 Abx 0 0 0 0 0
50 Abx 0 0 0 0 0
51 Abx 0 0 0 0 0
52 Abx 0 0 0 0 0
53 Abx nd nd nd nd nd
54 Abx nd nd nd nd nd
55 Abx nd nd nd nd nd
56 Abx nd nd nd nd nd
57 Abx nd nd nd nd nd
58 Abx nd nd nd nd nd
59 Abx nd nd nd nd nd
60 Abx nd nd nd nd nd
61 Abx 1 1 1 1 1
62 Abx 1 1 1 1 1
63 Abx 1 1 1 1 1
64 Abx 0 0 0 0 0
65 Abx nd nd nd nd nd
66 Abx nd nd nd nd nd
67 Abx nd nd nd nd nd
68 Abx nd nd nd nd nd
69 Abx nd nd nd nd nd
70 Abx nd nd nd nd nd
71 Abx nd nd nd nd nd
72 ExGF 0 0 0 0 0
73 ExGF 0 0 0 0 0
74 ExGF 0 0 0 0 0
75 ExGF 0 0 0 0 0
76 ExGF nd nd nd nd nd
77 ExGF nd nd nd nd nd
78 ExGF nd nd nd nd nd
79 ExGF nd nd nd nd nd
80 ExGF nd nd nd nd nd
81 ExGF nd nd nd nd nd
82 ExGF 1 1 1 1 1
83 ExGF 1 1 1 1 1
84 ExGF 1 1 1 1 1
85 ExGF 1 1 1 1 1
86 ExGF 2 2 2 2 2
87 ExGF nd nd nd nd nd
88 ExGF nd nd nd nd nd
89 ExGF nd nd nd nd nd
90 ExGF nd nd nd nd nd
91 ExGF nd nd nd nd nd
92 ExGF nd nd nd nd nd
93 ExGF nd nd nd nd nd
94 ExGF nd nd nd nd nd
95 ExGF nd nd nd nd nd
96 SCFA 0 0 0 0 0
97 SCFA 0 0 0 0 0
98 SCFA 0 0 0 0 0
99 SCFA 0 0 0 0 0
100 SCFA 0 0 0 0 0

Mouse Gut Microbiome and Motor Function (Hindlimb Clasping Scores) — AI Analysis

Germ-free mice had 55% lower hindlimb clasping scores than colonized mice (0.33 vs 0.73), linking gut microbiome to motor dysfunction

Recolonizing germ-free mice restored motor deficits (score rose to 0.67), confirming the microbiome's causal role

Key Findings

  • SPF (colonized) mice showed the worst motor function with a mean hindlimb score of 0.73 — 45% were impaired at score 1 or higher
  • Removing gut bacteria via germ-free conditions (GF, 0.33) or antibiotics (Abx, 0.36) cut motor impairment roughly in half
  • Recolonizing germ-free mice (ExGF) raised scores back to 0.67, nearly matching colonized levels — demonstrating the microbiome is sufficient to drive motor deficits
  • Short-chain fatty acids (SCFA, 0.54) partially reproduced the microbiome effect, suggesting bacterial metabolites mediate the gut-brain connection

Visualizations

Percentage of Mice with Motor Impairment
Mean Hindlimb Score by Treatment

This dataset contains 108 records across 6 fields: Motor function data for beam traversal, pole descent, adhesive removal, and hindlimb scores, , , , , .

108 rows · 6 columns · 2026-03-24

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Mouse Gut Microbiome Motor Function Hindlimb Clasping Scores

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