Humanized Mouse Motor Function: ASO vs Wild-Type in Parkinson's Disease Model

Motor function tests (beam cross, pole descent, adhesive removal, hindlimb score) comparing ASO and WT mice across healthy control and PD cohorts.
# Treatment
Genotype
Avg Beam cross time (sec)
Avg Pole descent time (sec)
Avg Adhesive removal time (sec)
Hindlimb score
+
1 HC1 WT 3.17 6.31 2.62 0
2 HC1 WT 4.07 5.79 0.67 0
3 HC1 WT 2.18 5.82 1.61 0
4 HC1 WT 2.35 4.36 2.03 1
5 HC1 WT 2.94 2.76 0.85 0
6 HC1 ASO 4.76 6.21 2.79 1
7 HC1 ASO 6.97 5.43 2.28 1
8 HC1 ASO 6.27 7.21 2.34 0
9 HC1 ASO 5.89 5.82 1.41 0
10 PD1 WT 2.77 6.31 0.71 0
11 PD1 WT 4.98 2.9 0.57 0
12 PD1 WT 4.46 2.97 0.51 0
13 PD1 WT 5.96 4.01 0.97 1
14 PD1 ASO 6.45 12.22 6.11 2
15 PD1 ASO 9.66 10.38 11.08 1
16 PD1 ASO 8.77 11.13 4.12 2
17 PD1 ASO 7.97 17.45 5.62 1
18 HC2 WT 3.46 12.24 2.76 0
19 HC2 WT 5.08 5.33 1.75 0
20 HC2 WT 5.49 3.72 1.32 0
21 HC2 ASO 5.54 5.54 4.63 0
22 HC2 ASO 4.82 3.48 6.99 0
23 HC2 ASO 9.71 6.35 5.48 1
24 HC2 ASO 5.97 6.49 5.19 0
25 PD2 WT 3.25 8.44 1.56 0
26 PD2 WT 3.98 3.37 1.53 0
27 PD2 WT 6.05 4.99 2.59 0
28 PD2 ASO 4.87 5.25 3.23 0
29 PD2 ASO 3.03 5.31 8.41 2
30 PD2 ASO 5.11 9.53 10.87 1
31 PD2 ASO 6.76 9.43 9.26 1
32 HC3 WT 5.03 6.33 2.46 0
33 HC3 WT 4.66 4.18 0.97 0
34 HC3 WT 4.06 3.78 2.9 1
35 HC3 WT 4.27 4.64 1.12 0
36 HC3 WT 4.11 3.57 1.76 0
37 HC3 ASO 5.71 7.37 2.43 2
38 HC3 ASO 7.41 12.55 3.62 1
39 HC3 ASO 4.57 9.89 3.48 1
40 HC3 ASO 3.62 16.79 2.31 0
41 HC3 ASO 7.24 12.15 3.46 1
42 PD3 WT 6.49 5.07 2.73 0
43 PD3 WT 6.97 3.96 1.16 0
44 PD3 WT 4.55 3.77 1.65 0
45 PD3 WT 9.35 7.08 0.67 0
46 PD3 WT 4.2 6.21 2.28 0
47 PD3 WT 5.41 4.2 0.83 0
48 PD3 ASO 15.64 11.94 6.05 1
49 PD3 ASO 15.06 12.52 7.29 1
50 PD3 ASO 8.27 9.65 4.18 2
51 PD3 ASO 4.31 8.68 4.59 1
52 PD3 ASO 11.37 17.5 5.73 1
53 HC4 WT 2.07 6.65 1.43 0
54 HC4 WT 2.01 8.42 1.71 0
55 HC4 WT 2.18 8.41 1.4 0
56 HC4 WT 2.05 5.43 0.91 0
57 HC4 ASO 6.61 6.69 3.23 0
58 HC4 ASO 3.62 11.39 4.06 0
59 HC4 ASO 5.78 11.79 7.13 0
60 HC4 ASO 7.27 9.97 3.15 1
61 HC4 ASO 3.61 8.85 4.17 1
62 PD4 WT 2.29 4.69 1.3 0
63 PD4 WT 2.86 5.66 1.3 0
64 PD4 WT 5.55 6.31 1.7 0
65 PD4 WT 3.45 4.41 2.57 0
66 PD4 ASO 7.1 14.02 3.28 2
67 PD4 ASO 11.03 16.45 7.41 1
68 PD4 ASO 8.92 13.86 4.88 0
69 PD4 ASO 17.45 13.17 4.31 2
70 HC5 WT 2.07 9.53 2.46 0
71 HC5 WT 2.82 5.53 1 0
72 HC5 WT 4.53 7.15 3.88 0
73 HC5 WT 1.8 5.07 1.44 0
74 HC5 ASO 5.39 12.42 1.28 0
75 HC5 ASO 3.84 13.11 3.21 1
76 HC5 ASO 3.02 8.78 4.23 1
77 HC5 ASO 3.77 7.61 5.8 2
78 HC5 ASO 4.19 11.24 1.87 1
79 PD5 WT 3.58 5.31 1.61 0
80 PD5 WT 2.96 4.03 0.96 0
81 PD5 WT 2.17 7.85 0.69 0
82 PD5 WT 1.86 5.27 1.68 0
83 PD5 ASO 5.06 17.89 4.38 1
84 PD5 ASO 3.76 18.39 6.19 1
85 PD5 ASO 3.53 19.62 4.94 2
86 PD5 ASO 5.95 12.44 4.39 2
87 PD5 ASO 6.21 19.03 6.68 1
88 HC6 WT 2.81 8.68 1.22 1
89 HC6 WT 3.88 5.78 1.6 0
90 HC6 WT 4.63 10.19 2.13 0
91 HC6 ASO 4.85 8.06 3.25 1
92 HC6 ASO 3.04 16.04 3.7 1
93 HC6 ASO 6.49 12.55 3.44 1
94 HC6 ASO 5.41 17.94 4.39 1
95 HC6 ASO 6.09 10.73 2.92 0
96 HC6 ASO 4.26 6.92 2.57 0
97 HC6 ASO 3.52 10.77 3.2 1
98 HC6 ASO 5.47 13.69 1.85 1
99 PD6 WT 3.16 4.29 1.16 0
100 PD6 WT 1.86 7.08 4.18 0

Humanized Mouse Motor Function: ASO vs Wild-Type in Parkinson's Disease Model — AI Analysis

PD-model ASO mice take 2.7x longer on pole descent than healthy WT controls (14.3 vs 5.3 sec), while WT mice show no PD-related deficit

Adhesive removal time is 3.6x worse in PD/ASO vs PD/WT mice (5.6 vs 1.6 sec), confirming genotype-specific motor impairment

Motor Function Summary

  • ASO mice show baseline motor deficits even in healthy controls: 57% slower beam crossing (5.3 vs 3.4 sec) and 57% slower pole descent (9.8 vs 6.2 sec) compared to WT
  • The PD model compounds ASO deficits dramatically — pole descent worsens 45% (9.8 → 14.3 sec) while WT pole descent is unchanged (6.2 → 5.3 sec)
  • Hindlimb clasping scores reveal the starkest contrast: PD/ASO averages 1.14 vs PD/WT at 0.04 — a 28x difference
  • Adhesive removal, a test of sensorimotor integration, shows the same pattern: ASO mice are 2x slower at baseline and 3.6x slower under PD conditions

Visualizations

Hindlimb Clasping Score by Group
Beam Cross Time by Group
Adhesive Removal Time by Group
Pole Descent Time by Group

Key Finding

Wild-type mice are remarkably resilient to the PD model — their motor performance is virtually identical in HC and PD conditions. This suggests the humanized ASO genotype is the primary driver of motor dysfunction, with the PD model acting as an amplifier rather than an independent cause.

This dataset contains 107 records across 6 fields: Treatment, Genotype, Avg Beam cross time (sec), Avg Pole descent time (sec), Avg Adhesive removal time (sec), Hindlimb score.

107 rows · 6 columns · 2026-03-22

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Humanized Mouse Motor Function Aso Wild Type Parkinson Disease Model

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